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Photoacoustic imaging (PAI) is a novel modality in biomedical imaging
technology that combines the rich optical contrast with the deep penetration of
ultrasound. To date, PAI technology has found applications in various
biomedical fields. In this review, we present an overview of the emerging
research frontiers on PAI plus other advanced technologies, named as PAI plus
X, which includes but not limited to PAI plus treatment, PAI plus new circuits
design, PAI plus accurate positioning system, PAI plus fast scanning systems,
PAI plus novel ultrasound sensors, PAI plus advanced laser sources, PAI plus
deep learning, and PAI plus other imaging modalities. We will discuss each
technology's current state, technical advantages, and prospects for
application, reported mostly in recent three years. Lastly, we discuss and
summarize the challenges and potential future work in PAI plus X area.

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