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which was really at the bottom of the suicide failed, oddly enough, just where my young lady’s assertion of her innocence failed also. It left Rosanna’s secret journey to Frizinghall, and Rosanna’s proceedings in the matter of the nightgown entirely unaccounted for. There was no use in pointing this out to Penelope; the objection made about as much impression on her as a shower of rain on a waterproof coat. The truth is, my daughter inherits my superiority to reason—and, in respect to that accomplishment, has got a long way ahead of her own father. On the next day (Sunday), the close carriage, which had been kept at Mr. Ablewhite’s, came back to …
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Latest: Aug. 29, 2022, 11:03 a.m.
e of her shortcomings towards others, under the influence, not of conviction and duty, but of sentiment and impulse! Most deplorable to think of—but, still, suggestive of something hopeful, to a person of my experience in plying the good work. There could be no harm, I thought, in ascertaining the extent of the change which the loss of her mother had wrought in Rachel’s character. I decided, as a useful test, to probe her on the subject of her marriage-engagement to Mr. Godfrey Ablewhite. Having first met her advances with all possible cordiality, I sat by her on the sofa, at her own request. We discussed family affairs and future plans—always e…
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Latest: Aug. 29, 2022, 11:03 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, pathology and management based on data from the existing literature and the experience of our own tertiary centre. Definitive diagnostic criteria for Nelson's syndrome are lacking. We argue in favour of a new set of criteria. We p…
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Latest: June 5, 2022, 12:42 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Muscular dystrophy can be a devastating diagnosis for children and their families. Understanding the potential course, prognosis, and genetic implications for the child and his/her family is dependent on the diagnosis of the specific type of dystrophy. This article suggests a sequential evaluation of children with possible muscular dystrophy and reviews the more common types. </p> </div>
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Latest: July 14, 2022, 8:26 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> <strong class="sub-title"> Background: </strong> Infections caused by <i> Candida </i> spp. have become one of the major causes of morbidity and mortality in immunocompromised patients. Therefore, new effective fungicides are urgently needed, especially due to an escalating resistance crisis. </p> <p> <strong class="sub-title"> Methods: </strong> A set of nanosystems with rod- (AuR), peanut- (AuP), and star-shaped (AuS) metal cores were synthesized. These gold nanopart…
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Latest: July 23, 2022, 7:24 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Mechanisms underlying human germ cell development are unclear, partly due to difficulties in studying human embryos and lack of suitable experimental systems. Here, we show that human induced pluripotent stem cells (hiPSCs) differentiate into incipient mesoderm-like cells (iMeLCs), which robustly generate human primordial germ cell-like cells (hPGCLCs) that can be purified using the surface markers EpCAM and INTEGRINα6. The transcriptomes of hPGCLCs and primordial germ cells (PGCs) isolated from non-human primates are similar, and although specification of hPGCL…
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Latest: June 7, 2022, 3:54 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> The Early Devonian Rhynie chert preserves the earliest terrestrial ecosystem and informs our understanding of early life on land. However, our knowledge of the 3D structure, and development of these plants is still rudimentary. Here we used digital 3D reconstruction techniques to produce the first well-evidenced reconstruction of the structure and development of the rooting system of the lycopsid <i> Asteroxylon mackiei </i> , the most complex plant in the Rhynie chert. The reconstruction reveals the organisation of the three distinct axis t…
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Latest: June 5, 2022, 2:58 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> We review the literature on uncertainty shocks and business cycle research. First, we motivate the study of uncertainty shocks by documenting the presence of time-variation in the volatility of macroeconomic time series. Second, we enumerate the mechanisms that researchers have postulated to link uncertainty shocks and business cycles. Third, we outline how we can specify uncertainty shocks. Fourth, we postulate a real business cycle model augmented with financial frictions and uncertainty shocks. Fifth, we use the model to illustrate our previous discussions an…
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Latest: July 10, 2022, 6:20 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Mating decisions are influenced by conspecifics' mate choices in many species including humans. Recent research has shown that women are more attracted to men with attractive putative partners than those with less attractive partners. We integrate these findings with traditional accounts of social signaling and test five hypotheses derived from it. In our study, 64 men and 75 women were paired with attractive and unattractive opposite-sex putative partners and asked whether they would prefer to give surveys to peers or to older adults. Consistent with predi…
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Latest: July 10, 2022, 6:42 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> "What's new in therapeutics?" will examine and evaluate drugs that may have a place in hospice, palliative, and long-term care. Mirtazepine will be examined and evaluated. Mirtazepine is a potential alternative anti-depressant with multiple additional benefits. It is an atypical anti-depressant, which has both noradrenergic and specific serotonergic receptor antagonism (NaSSa), and a unique pharmacological profile. Mirtazepine appears to be a "designer drug" for palliative medicine with a number of benefits, but cost may be a drawback. …
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Latest: July 14, 2022, 8:16 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Nelson's syndrome is a rare clinical manifestation that occurs in 8%-47% of patients as a complication of bilateral adrenalectomy, a procedure that is used to control hypercortisolism in patients with Cushing's disease. First described in 1958 by Dr. Don Nelson, the disease has since become associated with a clinical triad of hyperpigmentation, excessive adrenocorticotropin secretion, and a corticotroph adenoma. Even so, for the past several years the diagnostic criteria and management of Nelson's syndrome have been inadequately studied. The prima…
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Latest: June 5, 2022, 12:42 a.m.
(17), a market-town in Lincolnshire, on the Witham, 25 m. SW. of Lincoln, and has a fine 13th-century church; in the grammar-school Newton was educated, and in 1643 Cromwell won his first victory here; its industries embrace agricultural-implement making, malting, &amp;c. a 30 m. canal connects it with the Trent. GRANVILLE, GEORGE LEVESON-GOWER, second Earl, statesman; entered Parliament as a Liberal in 1836, and became a supporter of free trade; in 1846 succeeded to the peerage, and in 1851 became Foreign Minister under Lord John Russell; four years later became leader of the Lords; figured in every Liberal cabinet till 1886, usually as Co…
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Latest: Aug. 5, 2022, 6:55 p.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Although they are key to precision medicine, pharmacokinetics and pharmacogenomics are currently plagued with inconsistent results. In this issue of Cell Chemical Biology, Shimada et al. (2016) use cell line selectivity and appropriate filters to improve the consistency and to identify biomarkers for the selectivity of lethal compounds. These insights may be useful for our understanding of how necrosis and ischemic injury are regulated. </p> </div>
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Latest: July 14, 2022, 8:16 a.m.
ficiency; and they had with them a new Chinese invention, gunpowder, which they used in small field guns. He completed the conquest of the Kin Empire and then swept his hosts right across Asia to Russia (1235), an altogether amazing march. Kieff was destroyed in 1240, and nearly all Russia became tributary to the Mongols. Poland was ravaged, and a mixed army of Poles and Germans was annihilated at the battle of Liegnitz in Lower Silesia in 1241. The Emperor Frederick II does not seem to have made any great efforts to stay the advancing tide. Map: The Ottoman Empire before 1453 “It is only recently,” says Bury in his notes to Gibbon’s _Decl…
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Latest: Aug. 28, 2022, 4:59 a.m.
tbreak. Then there was a very tall, horse-faced old lady with an extraordinary dignity of bearing. She would sit framed in the window of her little house, like the picture of a _grande dame_ of the old régime. But every now and again she went on a wild burst, in the course of which she would skim plates out of the window at the passers-by. I was the only one who had influence over her at such times, for she was a haughty, autocratic old person. Once she showed an inclination to skim a plate at me also, but I quelled her by assuming a gloomy dignity as portentous as her own. She had some art treasures which she heaped upon me when she was what we w…
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Latest: June 15, 2022, 6:04 a.m.
profusely liberal.” In the pictures taken later in life, her face exhibits a very intellectual and animated expression, and there are traces of former beauty in the delicate features and bright black eyes. When the Indiana Territory which now forms the State of Indiana, was formed out of a portion of the old Northwestern Territory, General Harrison was appointed its first Governor by President Adams. He removed his family to the old French town of Vincennes, on the Wabash, then the seat of the Territorial Government, where Mrs. Harrison lived for many years a retired but very happy life. Dispensing with a liberal hand and courteous manner the…
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Latest: June 15, 2022, 7:34 a.m.
most other parts of the world at no cost and with almost no restrictions whatsoever. You may copy it, give it away or re-use it under the terms of the Project Gutenberg License included with this eBook or online at www.gutenberg.org. If you are not located in the United States, you will have to check the laws of the country where you are located before using this eBook. Title: Imre A Memorandum Author: Edward Irenaeus Prime-Stevenson Editor: Xavier Mayne Release Date: September 27, 2021 [eBook #66390] Language: English Produced by: anonymous Project Gutenberg volunteers …
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Latest: June 16, 2022, 11:10 p.m.
onymous with the free distribution of electronic works in formats readable by the widest variety of computers including obsolete, old, middle-aged and new computers. It exists because of the efforts of hundreds of volunteers and donations from people in all walks of life. Volunteers and financial support to provide volunteers with the assistance they need, is critical to reaching Project Gutenberg-tm's goals and ensuring that the Project Gutenberg-tm collection will remain freely available for generations to come. In 2001, the Project Gutenberg Literary Archive Foundation was created to provide a secure and permanent future for Project Gu…
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Latest: June 16, 2022, 11:30 p.m.
ations had enfeebled; or whether, finally, to the desolating commotion which the presence of this gray fiend excited in my whole nature--be that as it may, as I was on the point of signing I fell into a deep swoon and lay a long time as in the arms of death. Stamping of feet and curses were the first sounds which struck my ear as I returned to consciousness. I opened my eyes; it was dark; my detested attendant was busied scolding me. "Is not that to behave like an old woman? Up with you, man, and complete off-hand what you have resolved on, if you have not taken another thought and had rather blubber!" I raised myself with difficulty fr…
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Latest: June 17, 2022, 12:16 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> The colon serves as the habitat for trillions of microbes, which it must maintain, regulate, and sequester. This is managed by what is termed the mucosal barrier. The mucosal barrier separates the gut flora from the host tissues; regulates the absorption of water, electrolytes, minerals, and vitamins; and facilitates host-flora interactions. Colonic homeostasis depends on a complex interaction between the microflora and the mucosal epithelium, immune system, vasculature, stroma, and nervous system. Disruptions in the colonic microenvironment such as changes in m…
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Latest: June 7, 2022, 3:49 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> This paper explores the relationship between three illustrated alchemical treatises, all of which are associated with Jewish adepts: the famous Le Livre des figures hieroglyphiques attributed to Nicolas Flamel, and two treatises published in 1735 in Erfurt-the Uraltes Chymisches Werckh and the Donum Dei. The Werckh is supposedly written by Rabbi Abraham Eleazar, while the Donum Dei is attributed to an ancient alchemist-cabalist, Rabbi Samuel Baruch. I argue that these authors are fictitious, and that both works were in fact written in the early eighteenth centur…
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Latest: June 4, 2022, 10 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Nelson syndrome is an important complication of treatment with total bilateral adrenalectomy (TBA) for patients with refractory Cushing's disease. Although early cases of Nelson syndrome often presented with the clinical features of large sellar masses, the modern face of Nelson syndrome has changed primarily due to earlier detection (with highly resolved magnetic resonance imaging (MRI) and sensitive ACTH assays) and greater awareness of the condition, resulting in reduced morbidity and mortality. Although lack of administration of neoadjuvant pituitary ra…
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Latest: June 5, 2022, 12:42 a.m.
<div class="abstract-content selected" id="enc-abstract"> <p> Cough, Sputum, Fever: a Frequent Triad, but Not Always Banal <b> Abstract. </b> We report on a 72-year-old patient with known asthma who developed pneumonia after an infection-triggered exacerbation of the asthma. Based on this example we discuss the recommended diagnostic steps as well as the therapeutic decision and importance of follow-up observation. </p> </div>
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Latest: June 7, 2022, 3:50 a.m.
Abstract:A video compression system (Fig. 2) is disclosed that is optimized to take advantage of the types of redundancies typically occurring on computer screen (11) and the types of video loss acceptable to real time interative computer users (11). It automatically adapts to a wide variety of changing network (29) bandwidth conditions and can accommodate any video resolution and an unlimited number of colors. The video compression encoder can be implemented with either hardware or software and it compresses the source video into a series of data packets that are a fixed length of 8 bits or more. - Description: <invention-title lang="EN" …
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Latest: Aug. 5, 2022, 6:55 p.m.
<div class="abstract-content selected" id="enc-abstract"> <p> The demand for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular diagnostics that are faster, cheaper, and simpler to run than nasopharyngeal-based reverse transcription quantitative PCR (RT-qPCR) tests remains unmet in many parts of the world. In the Philippines, geographical and economic access to quality diagnostic testing remains out of reach for many communities. We describe the preclinical development of a fluorescence-based reverse transcription loop-mediated isothermal amplification test that uses drooled saliva as the biospecimen. S…
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Latest: June 4, 2022, 10 a.m.
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